8:00 h Registration

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9:00 h Opening Session

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Session 1. Chairperson - Luís S. Monteiro

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9:30 h PL1- Discovery and Development of Opicapone: A Potent and Peripherally Selective Catechol O-methyltransferase (COMT) Inhibitor for the Adjunctive Treatment of Parkinson’s Disease.

László Kiss, Medicinal Chemistry Manager, Laboratory of Chemical Research, Department of Research & Development, BIAL - Portela & Ca., S. A

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10:15 h IC1- Making the Use of Protein-Ligand Docking in Drug Discovery More Effective.

Sérgio Sousa, REQUIMTE, Faculty of Sciences, University of Porto.

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10:45 h OC1 - Metal ion complexes with pyridine-bis-oxazole.

A. Carvalho, Chemistry Centre, University of Minho.

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11:00 h OC2 - Dietary supplements phenolic profile and closely related bioactivity.

C. Pereira, Mountain Research Centre (CIMO), ESA, Polytechnic Institute of Bragança.

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11:15 h Coffee break and Poster Session

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Session 2. Chairperson - António G. Fortes

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11:45 h IC2 - How to discover and develop innovative medicines in Portugal? The example of redaporfin.

Luís Arnaut, Chemistry Centre of Coimbra, Department of Chemistry, University of Coimbra.

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12:15 h OC3 - A computational study on the transesterification reaction; modeling the reaction between scopine and MDTG.

L. M. S. Sobral, Hovione FarmaCiencia SA.

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12:30 h Lunch.

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Session 3. Chairperson - M. Fernanda Proença

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14:00 h PL2 - Biotransformation-induced toxicity. Challenges in drug design.

Maria Matilde S. D. Marques, Centre of Structural Chemistry, Department of Chemical Engeneering, Instituto Superior Técnico, Lisbon.

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14:45 h OC4 - Cationic phthalocyanines as a promising new approach for the inactivation of multi-resistant microorganisms.

Rafael T. Aroso, CQC, Department of Chemistry, University of Coimbra.

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15:00 h OC5 - Computational studies addressed to the catalytic mechanism of the alpha sub-unit of Tryptophan Synthase.

C. S. Silva-Teixeira, UCIBIO@REQUIMTE, Faculty of Sciences, University of Porto.

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15:15 h IC3 -  Discovery of Lead Molecules: Molecular Design, Synthesis and Pharmacology.

Carla Rosa, Head of Chemistry, Fine Chemistry Department, Tecnimede Group.

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15:45 h Coffee break and Poster Session

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16:30 h Round table - Moderator - Elsa Morais, Social Sciences Institute, University of Minho.

Participants:

Luís Arnaut, Chemistry Centre of Coimbra, Department of Chemistry, University of Coimbra.

Maria Matilde Marques, Head of the Division of Therapeutic Chemistry, Portuguese Chemistry Society.

Carla Rosa, Head of Chemistry, Fine Chemistry Department, Tecnimede Group.

Vera Duarte, Researcher CUF QI,  CUF - Industrial Chemicals.

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17:30 h Closing Remarks